A cost-efficient risk refinement tool for REACH (IWT-Postdoc)

Sensitivity and uncertainty analysis on risk assessment models

European risk assessment principles for new and existing chemicals are laid down in Commission Directives 93/67/EEC and 1488/94 and the Technical Guidance Documents (TGD). The chemical risk or safety assessment process is of an iterative nature. First, an initial, worst-case assessment is conducted after which refinements are made until no risk has been estimated or further refinements are not necessary. Wasting time and resources due to overly conservative parameters of these iterative processes should be avoided as much as possible, especially in view of the new chemical EU policy, REACH, which aims to assess tens of thousands of chemicals. This project aims to demonstrate the usefulness of a sensitivity and uncertainty analysis on the risk assessment model EUSES to identify and rank the most important “within-the-EU-TGD-reducible” parameters (or in a later phase processes and assumptions) influencing the local and regional risk characterisation. The ranking can be adjusted for the costs involved of additional testing (towards ecotoxicity, physico-chemical properties, emission estimates, etc…). The risk refinement tool therefore reduces the resources needed to obtain a realistic risk estimate (both more accurate or less conservative and less uncertain or more precise) as efficient as possible. The methodology is easily usable in Life Cycle Assessment as well.

Project duration: 2004-12-01 - 2006-12-31

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Frederik Verdonck
Department of Applied Mathematics, Biometrics and Process Control
Coupure Links 653
9000 Gent
Tel: +32 9 264 5935
Fax: +32 9 264 6220
Email: frederik.verdonck@biomath.ugent.be

Last update: 01 december 2008, webmaster@biomath.ugent.be

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